宋一之  研究員  

研究方向:

電子郵件:songyz@sibet.ac.cn

電       話:

通訊地址:蘇州市高新區科技城科靈路88號

簡       歷:

宋一之,研究員,2001年進入清華大學環境工程系學習,先后獲得工學學士、博士學位。2011-2018年期間先后在清華大學、英國謝菲爾德大學和英國牛津大學任博士后研究員。2018年參與創辦以開發臨床微生物診斷工具為目標的醫療器械企業。2020年加入中國科學院蘇州生物醫學工程技術研究所。長期以來主要從事病原微生物和單細胞分析等領域的研究,在微生物單細胞表型的拉曼光譜學、單細胞基因組擴增、臨床耐藥菌耐藥特征和合成生物學工具開發等領域取得了一系列重要的原創性成果。發表SCI收錄論文和英文專著章節31篇,獲得授權發明專利5項,實用新型專利授權3項。作為項目負責人承擔國家自然基金委面上、科技部重點研發計劃(子課題)、中科院裝備研制(子任務)、科技部基礎工作專項(子課題)等項目。多項研究成果已被轉化,受到市場一致認可。一項成果形成國家行業標準,成績較為突出。

獲獎及榮譽:

蘇州市領軍人才(2021

蘇州市高新區領軍人才(2020

上海市青年東方學者2019

社會任職:

研究方向:

(1)    病原菌感染精準診斷技術

(2)    細菌耐藥機制研究

(3)    新型拉曼光譜技術、設備開發與生物醫學應用

(4)    合成生物學

承擔項目情況:

代表論著:

1.      He J*, Gao R, Meng M, Yu M, Liu C, Li J, Song Y*, Wang H*. Lysophosphatidic Acid Receptor 6 (LPAR6) Is a Potential Biomarker Associated with Lung Adenocarcinoma. Int J Env Res Pub He 2021, 18(21): 11038.

2.      Wang J, Lin K, Hu H, Qie X, Huang WE, Cui Z, Gong Y, Song Y*. In Vitro Anticancer Drug Sensitivity Sensing through Single-Cell Raman Spectroscopy. Biosensor 2021, 11(8): 286.

3.         Yi X, Song Y*, et al , Analytical Chemistry, 2021 doi:10.1021/acs.analchem.0c04709

4.         Chen, J. X.; Lim, B.; Steel, H.; Song, Y.; Ji, M.; Huang, W. E., Redesign of ultrasensitive and robust RecA gene circuit to sense DNA damage. Microbial Biotechnology, 2021

5.         Jiang B, Song Y, Liu Z, Huang WE, Li G, Deng S, Xing Y, Zhang D. Whole-cell bioreporters for evaluating petroleum hydrocarbon contamination. Critical Reviews in Environmental Science and Technology 2020: 1-51.

6.         Song Y., et al. Overproduction of proteorhodopsin enhances long-term viability of Escherichia coli. Applied and environmental microbiology. 2020. 86(1) 02087-19

7.         Song, Y., Rampley, C. P. N., Chen, X., Du, F., Thompson, I. P., & Huang, W. E. (2019). Application of Bacterial Whole-Cell Biosensors in Health. In G. Thouand (Ed.), Handbook of Cell Biosensors (pp. 1-17). Cham: Springer International Publishing.

8.         Zhang, Q. Song, Y, et al. Monitoring Cr toxicity and remediation process combining a whole-cell bioreporter and Cr isotope techniques, Water Research, 2019. 153:295-303

9.         Liang, B., Gao, Y., Xu, J., Song, Y., Xuan, L., Shi, T., Chen, Z. J. Raman profiling of embryo culture medium to identify aneuploid and euploid embryos. Fertility and Sterility, 2019. 111(4), 753-762.e751.

10.     Jing, X., H. Gou, Y. Gong, X. Su, Xu, Y. Ji, Y. Song, I. P. Thompson, J. Xu and W. E. Huang, Raman-activated cell sorting and metagenomic sequencing revealing carbon-fixing bacteria in the ocean. Environ Microbiol. 2018( doi: 10.1111/1462-2920.14268.)

11.     Cui, Z., X. Luan, H. Jiang, Q. Li, G. Xu, C. Sun, L. Zheng, Y. Song, P. A. Davison and W. E. Huang, Application of a bacterial whole cell biosensor for the rapid detection of cytotoxicity in heavy metal contaminated seawater. Chemosphere 2018. 200: 322-329.

12.     Yuan, X., Song Y., Song Y., et al., Effect of laser irradiation on cell function and its implications in Raman spectroscopy. Applied and Environmental Microbiology, 2018.(doi:10.1128/AEM.02508-17)

13.     Song, Y, Kaster AK, Vollmers J, Song Y, Davison PA, Frentrup M, et al. Single-cell genomics based on Raman sorting reveals novel carotenoid-containing bacteria in the Red Sea. Microb Biotechnol. 2017;10(1):125-37

14.     Song, Y., et al., Raman-Deuterium Isotope Probing for in-situ identification of antimicrobial resistant bacteria in Thames River. Scientific Reports, 2017. 7(1): p. 16648

15.     Xu J., Zhu D., Ibrahim D., Allen R., Gibson M., Fowler W., Song Y., et al. Raman Deuterium Isotope Probing Reveals Microbial Metabolism at the Single-Cell Level. Analytical Chemistry, 2017. 89(24): p. 13305-13312

16.     Wang Y, Song Y, Tao Y, Muhamadali H, Goodacre R, Zhou N-Y, Preston GM, Xu J, Huang WE. 2016. Reverse and Multiple Stable Isotope Probing to Study Bacterial Metabolism and Interactions at the Single Cell Level. Analytical Chemistry 88:9443-9450

17.     Song, Y., H. Yin, and W.E. Huang, Raman activated cell sorting. Current Opinion in Chemical Biology, 2016. 33: 1-8

18.     Song, Y., et al., A whole-cell bioreporter approach for the genotoxicity assessment of bioavailability of toxic compounds in contaminated soil in China. Environ Pollut, 2014. 195: 178-84

19.     Song Y., Zhang D., Karen P., et al. Bacterial Whole-Cell Biosensors in Environmental Health // Victor R. Preedy. Biosensors and Environmental Health. CRC Press: Boca Raton, 2012

20.     Song, Y., G. Li, etc., Optimization of Bacterial Whole Cell Bioreporters for Toxicity Assay of Environmental Samples, Environmental Science & Technology, 2009. 43(20):7931-7938

21.     Song, Y. Z. Hahn, T. etc., Ultrasound-mediated DNA transfer for bacteria, Nucleic Acids Research, 2007. 35(19):e129

 

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