莊杰  研究員  

研究方向:

電子郵件:jzhuang@sibet.ac.cn

電       話:18300332517

通訊地址:蘇州高新區科技城科靈路88號

簡       歷:

莊杰,博士,研究員,中科大博士生導師。

先后在廈門大學、北京大學和美國Old Dominion大學獲學士、碩士和博士學位,博士導師為超短高壓脈沖電場腫瘤消融技術奠基人、IEEE終身會士Karl Schoenbach教授,2012年加入德國萊布尼茨等離子體研究所(INP Greifswald)任研究員,2017年底回國加入中科院蘇州醫工所。曾獲富林沃斯國際青年創新獎,“春暉杯”留學人員創新創業大賽優勝獎以及IEEE DEIS獎學金等國內外獎項。國家重點研發計劃項目負責人,國際生物電協會技術委員會委員,中國電工技術學會等離子體及應用專業委員會委員,中國電工技術學會青年工作委員會委員,蘇州市高新區創業領軍人才,IEEE Transaction on Plasma Science客座編輯,發表SCI論文30余篇,申請和授權國內外發明專利10多項。課題組現有博士學位研究人員5人(美國博士2人,德國博士1人,北大、國科大博士各一人),專業背景涵蓋電子電氣、生物醫學、物理學以及人工智能等領域,研究生14人,訪問交流人員4人。

中科大招生導師簡介:http://dsxt.ustc.edu.cn/zj_js.asp?zzid=6502

獲獎及榮譽:

社會任職:

研究方向:

主要研究方向為生物電(Bioelectrics),包括高壓超短脈沖電場和大氣低溫等離子體的生物醫學與環境應用,參與和主持了美國空軍、美國國防部、IEEE DEIS學會、德國聯邦教育與研究部、中科院、科技部等多個項目。

1. 脈沖電場的生物醫學應用:高壓納秒脈沖電場能夠在細胞膜和細胞器膜上擊穿出數以百萬計的納米小孔,誘發癌細胞凋亡,與現有同類技術相比具有神經、血管和細胞外基質損傷小、炎癥反應低等顯著優勢,是新一代的非熱實體腫瘤消融技術。此外高壓脈沖電場技術在軟組織消融、美容和細胞治療等眾多領域都有巨大的應用潛力。

2. 等離子體醫學:由氣體放電而產生的大氣低溫等離子體,其中的活性基團(ROS、RNS等)和電場等成分可以直接作用于人體,在滅菌消毒、傷口治療以及腫瘤治療等領域有廣闊的應用前景。

3. 生物介電譜診斷技術(dielectric spectroscopy):介電譜技術能夠在原位高速、無創地對生物細胞和組織的寬頻電學參數(電導率、介電常數)進行測量,無需添加任何標記物,對細胞膜的結構變化尤其敏感??捎糜谠\斷各種物理、化學因子對生物細胞和組織的作用,如術中實時評估脈沖電場對組織電穿孔和消融的效果。

承擔項目情況:

代表論著:

1) Nanosecond pulsed electric fields impair viability and mucin expression in mucinous colorectal carcinoma cell - Bioelectrochemistry - 2021 - accepted

2) Potential use of atmospheric cold plasma for postharvest preservation of blueberries - Postharvest Biology and Technology - 2021 - accepted

3) Combination of metformin and cold atmospheric plasma induces glioma cell death to associate with c-Fos - Neoplasma - 2021 - Vol 68, no. 1, pp. 126-134

4) 大氣壓低溫等離子體射流制備刺激響應型凝膠 - 電工技術學報 - 2021 - accepted

5) Comparative transcriptome analysis of atmospheric pressure cold plasma enhanced early seedling growth in Arabidopsis thaliana - Plasma Science and Technology - 2021 - accepted

6) Visible-light-driven photocatalytic inactivation of S. aureus in aqueous environment by hydrophilic zinc oxide (ZnO) nanoparticles based on the interfacial electron transfer in S. aureus/ZnO composites - Journal of Hazardous Materials - 2021 - accepted

7) Impedimetric Characterization of Normal and Cancer Cell Responses after Nano-pulse Stimulation - Journal of Physics D: Applied Physics - 2021 - Vol. 54, no. 18, pp. 185401

8) Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium - Advanced Science - 2020 - Vol. 7, no. 1, pp. 1902089

9) Discrimination of different cell monolayers before and after exposure to nanosecond pulsed electric fields based on Cole–Cole and multivariate analysis - Journal of Physics D: Applied Physics - 2019 - 52 (2019) 495401

10) Bioimpedance Analysis of Epithelial Monolayers after Exposure to Nanosecond Pulsed Electric Fields - IEEE Transactions on Biomedical Engineering - 2018 - VOL. 66, NO. 7

11) Cobalt Containing Polyimide Films Treated by Nanosecond Pulsed Electrical Discharges in Water - IEEE Transactions on Plasma Science - 2016 -

12) Dielectric Spectroscopy of Polyimide Films Treated by Nanosecond High Voltage Pulsed Driven Electrical Discharges in Water - Plasma Processes and Polymers - 2016 -

13) Predicting the prevalence of peripheral arterial diseases: modeling and validation in different cohorts - European Journal of Vascular Medicine - 2016 -

14) Formation mechanism of streamer discharges in liquids: a rev - High Voltage - 2016 -

15) Time Domain Dielectric Spectroscopy of Nanosecond Pulsed Electric Field Induced Changes in Dielectric Properties of Pig Whole Blood - Bioelectrochemistry - 2015 -

16) Piezoelectric-Enhanced Oriented Cobalt Coordinated Peptide Monolayer with Rectification Behavior - Small - 2015 -

17) Self-Reported Insomnia and Coronary Heart Disease in the Elderly - Clinical and Experimental Hypertension - 2015 -

18) Synergistic Antibacterial Effects of Treatments with Low Temperature Plasma Jet and Pulsed Electric Fields - Applied Physics Letters - 2014 -

19) Measuring dielectric properties of biological cells as a function of temperature - 2014 IEEE International Power Modulator and High Voltage Conference - 2014 -

20) Compact high-voltage, low-impedance nanosecond pulse generators for biomedical applications - IEEE International Conference on Plasma Science - 2014 -

21) Changes in gap junction-mediated intercellular communication in a cell-monolayer after the exposure to nanosecond pulsed electric fields - IEEE Pulsed Power Conference - 2013 -

22) Effect of pulsed electric fields on cell-cell-communication via gap junctions in cell-monolayers - IEEE International Conference on Plasma Science - 2013 -

23) Operation of a cold DC operated air plasma jet for microbial decontamination - IEEE International Conference on Plasma Science - 2013 -

24) Dielectric response of cancer cells after exposure to single and multiple nanosecond pulses - IEEE International Conference on Plasma Science - 2013 -

25) Long term survival of mice with hepatocellular carcinoma after pulse power ablation with nanosecond pulsed electric fields - Technology in Cancer Research & Treatment - 2012 -

26) Dielectric Evolution of Mammalian Cell Membranes after Exposure to Pulsed Electric Fields - IEEE Transactions on DEI - 2012 -

27) Pulsed electric field induced dielectric evolution of mammalian cells - Proceedings of IEEE IPMHV Conference - 2012 -

28) Pulsed electric field induced conformational changes of mammalian cells revealed by time domain dielectric spectroscopy - IEEE International Conference on Plasma Science - 2012 -

29) Microfluidic impedance spectroscopy as a tool for quantitative biology and biotechnology - Biomicrofluidics - 2012 -

30) Cell Death Induced by Subnanosecond Pulsed Electric Fields at Elevated Temperatures - IEEE Transactions on Plasma Science - 2012 -

31) Modification of dielectric characteristics of cells by intense pulsed electric fields - Proceedings of IEEE Pulsed Power Conference - 2011 -

32) Time domain dielectric spectroscopy of biological cells after pulsed electric field exposure - IEEE CEIDP Conference - 2011 -

33) Pulsed electric field induced changes in dielectric properties of biological cells - IEEE IPMHV Conference - 2010 -

34) Pulsed discharges for medical applications - IEEE International Conference on Plasma Science - 2010 -

35) Pulsed electric field induced changes in dielectric properties of biological cells - 2009 IEEE Pulsed Power Conference - 2009 -

36) Tumor treatment with nanosecond pulsed electric fields - 2009 IEEE Pulsed Power Conference - 2009 -

37) First response of mammalian cells to nanosecond pulsed electric fields - IEEE International Conference on Plasma Science - 2008 -

38) Nanosecond Pulse Generator with Variable Pulse Duration for the Study of Pulse Induced Biological Effects - IEEE IPMHV Conference - 2008 -

39) Dynamic Contrast-Enhanced Magnetic Resonance Images of the Kidney - IEEE Engineering in Medicine and Biology Magazine - 2008 -

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