張京鐘  研究員  

細胞工程研究中心主任

研究方向:

電子郵件:zhangjz@sibet.ac.cn

電       話:13913161723,0512-69588288

通訊地址:

簡       歷:

張京鐘博士,中國科學院蘇州生物醫學工程技術研究所研究員,細胞工程研究中心負責人,中國科學技術大學博士生導師。2005年獲得神經生物學博士,在Helmholtz慕尼黑中心、德國環境健康研究中心從事神經發育、干細胞分化機制和干細胞轉分化研究十余年。在重大疾病的干細胞治療和基因治療研究中取得了較多成果,獲得江蘇省高層次創新創業人才、姑蘇重大創新團隊領軍人才、北京市科技新星、北京市科技進步二等獎、中華醫學科技獎三等獎等榮譽稱號和獎項。發表論文40余篇,申請專利10余項,授權發明專利2項,獲得各級經費2600萬元。

獲獎及榮譽:

社會任職:

1. 中國神經科學學會神經干細胞和組織工程分會,委員。

2. 中國環境誘變劑學會風險評價專業委員會,委員。

3. 中國生物醫學工程第九屆青年工作委員會,委員。

4. 中國醫學裝備協會輸血醫學裝備技術專委會,委員。

5. 國家重點研發計劃、國家重大科技專項評審專家。

6.       國家空間站工程航天醫學實驗領域專家委員會委員。

7. 中國生物工程學會干細胞與組織工程專委會常務委員。

研究方向:

1)干細胞/類腦器官治療神經系統重大疾??;(2)基于皮膚類器官的組織工程材料修復難治性創面;(3)干細胞/免疫細胞標準化制備技術和相關裝備研發。

承擔項目情況:

1.     姑蘇重大創新團隊項目:干細胞關鍵技術研發及其核心裝備產業化開發(領軍人才,經費:1000萬元)。

2.     江蘇省重點研發計劃:基于CRISPR/Cas9技術制備可多模態示蹤多巴胺神經元及其治療帕金森病的臨床前研究(項目負責人,經費:300萬元)。

3.     中科院戰略性先導科技專項(A類):三維培養及人工皮膚三維重建裝置為基礎的皮膚類器官構建(任務聯合負責人,經費:300萬元)

代表論著:

1.        Zhang L, Yan X, An L, Wang M, Xu X, Ma Z, Nie M, Du F, Zhang J*, Yu S. A pneumatically assisted atomization device for living cell delivery and application of sprayed mesenchymal stem cells in skin regeneration. Bio design and manufacturing, 2021 (accepted). (Co-corresponding author )

2.        Yao Zhou, Jinhua Zhou, Xi Xu, Fangzhou Du, Mengting Nie, Lvzhong Hu, Yuhao Ma, Mengmeng Liu, Shuang Yu, Jingzhong Zhang*, Youguo Chen. Matrigel/umbilical cord-derived mesenchymal stem cells promote granulosa cell proliferation and ovarian vascularization in a mouse model of premature ovarian failure. Stem Cells and Development. 2021;(Accepted) (Co-corresponding author )

3.        An L, Tao Q, Wu Y, Wang N, Liu Y, Wang F, Zhang L, Shi A, Zhou X, Yu S, Zhang J*. Synthesis of SPIO nanoparticles and the subsequent applications in stem cell labeling for Parkinson's disease. Nanoscale Res Lett, 2021, 16:107. (Corresponding author )

4.        Zongfang Li, Wei Zhao, Bo He, Tong San Koh, Yanxi Li, Yizhen Zeng , Zhuo Zhang, Jingzhong Zhang, Zujun Hou. Application of Distributed Parameter Model to Assessment of Glioma IDH Mutation Status by Dynamic Contrast-Enhanced Magnetic Resonance Imaging. Contrast Media Mol Imaging, 2020 Nov 22;2020:8843084.

5.        Jana Heppt, Marie-Theres Wittmann, Jingzhong Zhang, Daniela Vogt-Weisenhorn, Nilima Prakash, Wolfgang Wurst, Makoto Mark Taketo, D. Chichung Lie. β-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons. EMBO Journal, 2020 Nov 2; 39(21): e104472.

6.        Yan Liu, Yehui Zhou, Kuo-Hsiang Huang, Xujie Fang, Ying Li, Feifei Wang, Li An, Qingfei Chen, Yunchao Zhang, Aihua Shi, Shuang Yu, and Jingzhong Zhang*. Targeting epidermal growth factor-overexpressing triple-negative breast cancer by natural killer cells expressing a specific chimeric antigen receptor. CELL PROLIFERATION, 2020;00:e12858 (Corresponding author )

7.        Qingfei Chen, Feifei Wang, Yunchao Zhang, Yan Liu, Li An, Zhongliang Ma, Jingzhong Zhang*, Shuang Yu. Neonatal DEX exposure leads to hyperanxious and depressive-like behaviors as well as a persistent reduction BDNF expression in developmental stages. Biochemical and Biophysical Research Communications, 2020, Vol.527(1): 311-316 (Co-corresponding author )

8.        Yang Z, Zheng C, Zhang F, Lin B, Cao M, Tian X, Zhang J, Zhang X, Shen J. Magnetic resonance imaging of enhanced nerve repair with mesenchymal stem cells combined with microenvironment immunomodulation in neurotmesis. Muscle Nerve. 2020 Mar 14. doi: 10.1002/mus.26862.

9.        Mao J, Cao M, Zhang F, Zhang J, Duan X, Lu L, Yang Z, Zhang X, Zhu W, Zhang Q, Wang Z, Shen J. Peritumoral administration of IFNβ upregulated mesenchymal stem cells inhibits tumor growth in an orthotopic, immunocompetent rat glioma model. J Immunother Cancer. 2020 Mar;8(1). pii: e000164. doi: 10.1136/jitc-2019-000164.

10.    Liu Y, Song H, Yu S, Huang K-H, Ma X, Zhou Y, Zhang J*, Chen L. Protein Kinase D3 promotes the cell proliferation by activating the ERK1/c‐MYC axis in breast cancer. J Cell Mol Med.,2020;24:2135–2144. (Co-corresponding author )

11.    Liu Y, Zhou Y, Huang KH, Li Y, Fang X, An L, Wang F, Chen Q, Zhang Y, Shi A, Yu S, Zhang J*. EGFR-specific CAR-T cells trigger cell lysis in EGFR-positive TNBC. Aging (Albany NY). 2019 Dec 4;11(23):11054-11072. (Corresponding author )

12.    Yan Liu,Yuzhi Wang,Shiyi Yu,Yehui Zhou,Xinxing Ma,Qian Su,Li An,Feifei Wang,Aihua Shi, Jingzhong Zhang*,Liming Chen. The Role and Mechanism of CRT0066101 as An Effective Drug for Treatment of Triple-Negative Breast Cancer. Cellular Physiology and Biochemistry, 2019;52(3):382-396. (Co-corresponding author )

13.    Yu N, Zhang X, Gao Y, You H, Zhang J*, Miao P. Highly Sensitive Endotoxin Assay Combining Peptide/Graphene Oxide and DNA-Modified Gold Nanoparticles. ACS Omega. 2019, 22; 4(10): 14312-14316. (Co-corresponding author )

14.    Liu Y, Li J, Ma Z, Zhang J, Wang Y, Yu Z, Lin X, Xu Z, Su Q, An L, Zhou Y, Ma X, Yang Y, Wang F, Chen Q, Zhang Y, Wang J, Zheng H, Shi A, Yu S, Zhang J, Zhao W, Chen L. Oncogenic functions of Protein Kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. Cancer Med. 2019;8(2):729-741.

15.    Zhenzhen Guo, Jun Xu, Jingzhong Zhang, Yayun Hu, Yue Pan, Peng Miao. Facile Strategy for Electrochemical Analysis of Hydrogen Peroxide Based on Multifunctional Fe3O4@Ag Nanocomposites. ACS Appl. Bio Mater. 2018, 1, 367?373.

16. Yu S,Zutschi I, Stoffel R, Zhang JZ, Silva PV, Sousa N, Costa PS, Holsboer F, Patchev A, Almeida OF.. Antidepressant responsiveness in adulthood is permanently impaired after neonatal destruction of the neurogenic pool. Trans Psychiatry. 2017, 71):1~9.

17. Garrett L*, Zhang, J. *, Annemarie Zimprich, Kristina M. Niedermeier, Helmut Fuchs, Valerie Gailus-Durner, Martin HrabMe de Angelis, Daniela Vogt Weisenhorn, Wolfgang Wurst and Sabine M. H?lter. Conditional Reduction of Adult Born Doublecortin-Positive Neurons Reversibly Impairs Selective Behaviors. (*Co-first author) Frontiers in Behavioral Neuroscience. 2015,9:302.

18.    Yoshiyasu Fukusumi, Florian Meier, Sebastian G?tz, Friederike Matheus, Martin Irmler, Theresa Faus-Kessler, Eleonora Minina, Benedict Rauser, Jingzhong Zhang, Elizabeth Andersson, Johan Ericson, Meng Li, Christof Niehrs, Antonio Simeone, Johannes Beckers, Wolfgang Wurst and Nilima Prakash. Dickkopf 3 Promotes the Differentiation of Substantia Nigra Dopaminergic Neurons In Vivo and from Pluripotent Stem Cells In Vitro. Jounal of Neuroscience. 2015, 35(39):13385–13401.

19.    Marina Theodorou, Benedict Rauser, Jingzhong Zhang, Nilima Prakash, Wolfgang Wurst, Joel A. Schick. Limitations of in vivo reprogramming to dopaminergic neurons via a tricistronic strategy. Human gene therapy Methods. 2015, 26(4):107-22.

20.    Jingzhong Zhang, Sebastian G?tz, Daniela M. Vogt Weisenhorn, Antonio Simeone, Wolfgang Wurst and Nilima Prakash. A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1+/– mice. Neurobiology of Disease. 2015,82: 32-45.

21.    Michaela Matthes*, Martin Preusse*, Jingzhong Zhang*, Julia Schechter, Daniela Mayer, Bernd Lentes, Fabian Theis, Nilima Prakash, Wolfgang Wurst, Dietrich Trümbach. Mouse IDGenes: A reference database for genetic interactions in the developing mouse brain. (*Co-first author) Database: The Journal of Biological Databases and Curation, 2014 Aug 20;2014. pii: bau083.1-16.

22.    Giesert F, Hofmann A, Bürger A, Zerle J, Kloos K, Hafen U, Ernst L, Zhang J, Vogt-Weisenhorn DM, Wurst W. Expression analysis of lrrk1, lrrk2 and lrrk2 splice variants in mice. PLoS One . 2013, 8(5) e63778

23.    Peng C, Li N, Ng YK, Zhang J, Meier F, Theis FJ, Merkenschlager M, Chen W, Wurst W, Prakash N. A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation. Jounal of Neuroscience. 2012, 32:13292-13308.

24.    Glasl L, Kloos K, Giesert F, Roethig A, Di Benedetto B, Kühn R, Zhang J, Hafen U, Zerle J, Hofmann A, de Angelis MH, Winklhofer KF, H?lter SM, Vogt Weisenhorn DM, Wurst W. Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb. Exp Neurol., 2012, 235: 214-227.

25.    Zhang J, Giesert F, Kloos K, Vogt Weisenhorn DM, Aigner L, Wurst W, Couillard-Despres S. A powerful transgenic tool for fate mapping and functional analysis of newly generated neurons. BMC Neurosci., 2010, 11: 158.

26.    Yu S, Patchev AV, Wu Y, Lu J, Holsboer F, Zhang JZ, Sousa N, Almeida OF. Depletion of the neural precursor cell pool by glucocorticoids. Ann Neurol., 2010, 67:21-30.

27.    Yu S, Zhang JZ, Xu Q. Genes associated with neuronal differentiation of precursors from human brain. Neuroscience , 2006, 141: 817-825.

28.    Zhang Jingzhong, Yang Hui, Duan Deyi, Duan Chunli, Zhao Chunli, Sun Xiaohong, Zhang Jinlu, Xu Qunyuan. Long-term therapeutic effects on parkinsonian rats of intrastriatal co-grafts with genetically engineered fibroblasts expressing tyrosine hydroxylase and glial cell line-derived neurotrophic factor. Int J Neurosci., 2005, 115: 769-779.

29.    Duan D, Yang H, Zhang J, Zhang J, Xu Q. Long-term restoration of nigrostriatal system function by implanting GDNF genetically modified fibroblasts in a rat model of Parkinson’s disease. Exp Brain Res., 2005, 161: 316-324.

30.    S. Yu, J.Z. Zhang, C.L. Zhao, H.Y. Zhang Q. Xu. Isolation and characterization of the CD133+ precursors from the ventricular zone of human fetal brain by magnetic affinity cell sorting. Biotechnol Lett, 2004, 26: 1131–1136.

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