馬勇  研究員  

研究方向:

電子郵件:mayong@sibet.ac.cn

電       話:0512-69588328

通訊地址:蘇州高新區科靈路88號

簡       歷:

從事制藥和生物技術領域的研究與開發的工作十余年。2014年回國任中國科學院“百人計劃”特聘研究員,博士生導師,中國科學院蘇州生物醫學工程技術研究所核酸檢測技術研究中心副主任。北京大學生物學學士學位,美國約翰霍普金斯大學醫學院分子生物學博士和博士后?;貒跋群髶蚊绹硸|制藥公司(MSD, Merck & Co., Inc.)高級生物學家,Quintara Biosciences科學家和BioChain Institute, Inc.科學家兼項目負責人。在癌癥相關的信號傳導途徑、RNA干擾、功能性基因組學、細胞檢測方法開發、活體和體外藥物靶標的鑒定和驗證等方面具有豐富的理論與研發經驗。在國際頂級科研雜志(《細胞》、《自然》等)發表多篇論文,并在美國專利和商標局申請有多項專利?;貒詠?,在研或驗收包括國家重點專項、省專項等科研人才類項目十余項,發表科研論文和專利三十多篇(項)。國家高端外國專家、江蘇省免疫學會委員、江蘇省“引智計劃”、蘇州市海鷗計劃、蘇州市“高等院校、科研院所緊缺高層次人才、蘇州市優秀人才等。

獲獎及榮譽:

1、 國家高端外國專家(2021

2、 江蘇省“引智計劃”(2020

3、 蘇州市“海鷗計劃”(2020

4、 蘇州市優秀人才貢獻獎(2018

5、 蘇州市高等院校、科研院所緊缺高層次人才(2017

6、 中國科學院百人計劃2014

7、 開發了兩個癌癥早期篩查與診斷的體外分子診斷試劑盒

8、 用活體RNA干擾技術驗證了3個癌癥藥物靶標

9、 向美國專利與商標局申請了3個用RNA干擾技術抑制基因表達的發明專利,其中1個已授權

10、 作為第一作者在英國《自然》雜志(Nature)發表了一篇具有里程碑意義的科研論文,且這篇論文引發了在不同雜志上發表的多篇評論文章

11、 作為第一作者在美國《細胞》雜志(Cell)發表了一篇科研論文

12、 作為共同作者在美國《細胞》雜志(Cell)發表了兩篇科研論文

13、 入選美國最悠久的學術榮譽協會-ΦΒΚ協會(2003

14、 博士學位候選人口試表現出色的特別表彰(1997

社會任職:

研究方向:

1、 體外分子診斷方法和應用

2、 癌癥早期篩查和診斷

3、 核酸雜交與結構

 

 

承擔項目情況:

代表論著:

1.       Qianqian Wang, Daniel E.Asarnow, Ke Ding, Randall K. Mann, Janson Hatakeyama, Yunxiao Zhang, Yong Ma, Yifan Cheng*, Philip A.Beachy*, Dispatched uses Na+  flux to power release of  lipid-modified Hedgehog, Nature, 2022.SCI

2.       Yang Cao, Guodong Zhao, Yaping Tian, Zhiliang Chen, Xiaoyu Liu, Mufa Yuan, Jun Yang, Xiaomei Wang, Yong Ma, Zhaocheng Liu, Shangmin Xiong*, Minxue Zheng*, Sujuan Fei*, Feasibility of methylated CLIP4 in stool for early detection of colorectal cancer: a training study in Chinese population, Frontiers in Oncology, 2021.SCI

3.       Guoying Zhang, Fang He, Guodong Zhao, Zizhui Huang, Xiang Li, Xia Xia, Yidi Guo, Weiping Xu, Shangmin Xiong, Yong Ma, Minxue Zheng*, Wanli Liu*, Combining serum DNA methylation biomarkers and protein tumor markers improved clinical sensitivity for early detection of colorectal cancer, International Journal of Genomics, 2021.SCI

4.       Zhaocheng Liu, Chengxue Zhao, Guodong Zhao, Shangmin Xiong*, Yong Ma*, Minxue Zheng*, Disruptors, a new class of oligonucleotide reagents, significantly improved PCR performance on templates containing stable intramolecular secondary structures, Analytical Biochemistry, 2021.SCI

5.       Guodong Zhao, Xiaoyu Liu, Yi Liu, Yong Ma, Jun Yang, Hui Li, Shangmin Xiong, Sujuan Fei,* Minxue Zheng*, Xiangwei Zhao*, Methylated SFRP2 and SDC2 in Stool Specimens for Colorectal Cancer Early Detection: A Cost-effective Strategy for Chinese Population, Journal of Cancer, 2021.SCI

6.       Yaping Cao, Guodong Zhao, Mufa Yuan, Xiaoyu Liu, Yong Ma, Yang Cao, Bei Miao, Shuyan Zhao, Danning Li, Shangmin Xiong*, Minxue Zheng*, Sujuan Fei*, KCNQ5 and C9orf50 methylation in stool DNA for early detection of colorectal cancer, Frontiers in Oncology, 2021.SCI

7.       Guodong Zhao, Zhengzheng Wang, Shangmin Xiong, Xiaoyu Liu, Yun Zhu, Shiming Li, Yong Ma*, Minxue Zheng*, Feasibility of Multiplex Methylated DNA Testing in Serum for Detection of Upper Gastrointestinal Tract Cancers, Test Engineering and Management, 2020.SCI

8.       Guodong Zhao, Xiaoyu Liu, Yi Liu, Hui Li, Yong Ma, Shiming Li, Yun Zhu, Jin Miao, Shangmin Xiong*, Sujuan Fei*, Minxue Zheng*, Aberrant DNA Methylation of SEPT9 and SDC2 in Stool Specimens as an Integrated Biomarker for Colorectal Cancer Early Detection, Front Genet, 2020.SCI

9.       Guodong Zhao, Yong Ma, Hui Li, Shiming Li, Yun Zhu, Xiaoyu Liu, Shangmin Xiong, Yi Liu, Jin Miao, Sujuan Fei*, Minxue Zheng*, Xiangwei Zhao*, A novel plasma based early colorectal cancer screening assay based on methylated SDC2 and SFRP2, Clinica Chimica Acta, 2020.SCI

10.   Jin Miao?, Yi Liu?, Guodong Zhao, Xiaoyu. Liu, Yong Ma, Hui Li, Shiming Li, Yun Zhu, Shangmin Xiong*, Minxue Zheng*, Sujuan Fei*,  Feasibility of plasma methylated SFRP2 for early detection of gastric cancer, Cancer Control, 2020.SCI

11.   Guodong Zhao, Yi Liu, Jin Miao, Hui Li , Yong Ma, Xiaoyu Liu, Shiming Li, Yun Zhu, Shangmin Xiong*, Minxue Zheng*, Sujuan Fei*, Performance comparison between plasma and stool methylated SEPT9 tests for detecting colorectal cancer, Frontiers in Genetics, 2020.SCI

12.    Zhaocheng Liu, Jinli Sun, Guodong Zhao, Shangmin Xiong*, Yong Ma*, Minxue Zheng*, Transient stem-loop structure of nucleic acid template may interfere with__polymerase chain reaction through endonuclease activity of Taq DNA__polymerase, Gene, 2020.SCI

13.   Guodong Zhao, Hui Li, Zixuan Yang, Zhenzhen Wang, Shangmin Xiong, Shiming Li, XiaoTing Wu, Xiaoyu Liu, Ziwen Wang, Yun Zhu, Yong Ma*, Sujuan Fei*, Minxue Zheng*, Multiplex Methylated DNA Testing in Plasma with High Sensitivity and Specificity for Colorectal Cancer Screening, Cancer Medicine, 2020.SCI

14.   Jinli Sun, Yaping Tian, Yingying Du, Zhenzhen Wang, Guodong Zhao*, Yong Ma*, Minxue Zheng*, A Cautionary Tale of Cross Contamination among Plasmids from Commercial Suppliers, Biotechniques, 2020.SCI

15.   Jinli Sun, Yang Shi, Guodong Zhao*, Yingying Du, Zhenzhen Wang, Zhaocheng Liu, Hui Wang, Yong Ma*, Minxue Zheng*, Rapid detection of diarrheagenic Escherichia coli in food by a new multiplex real-time Quantitative PCR Assay, Applied Biochemistry and Microbiology, 2020.SCI  

16.   Yingying Du, Guodong Zhao, Zhaocheng Liu, Jinli Sun, Minxue Zheng*, Yong Ma*, Comparison of CerviHPV and cobas 4800 HPV Tests for Detection of High-risk HPV Infection in Cervical Swab Specimens, Journal of Reproductive Medicine, 2020.SCI

17.   Hui Li, Zhenzhen Wang, Guodong Zhao, Yong Ma, Ying Chen, Qi Xue, Minxue Zheng*, Sujuan Fei*, Performance of a MethyLight assay for methylated SFRP2 DNA detection in colorectal cancer tissue and serum, The International Journal of Biological Markers, 2019. SCI

18.   Ying Chen, Zhenzhen Wang, Guodong Zhao, Chuang Sun, Yong Ma, Linyan Zhang, Minxue Zheng*, Hngchun Li*, Performance of a Novel Blood based Early Colorectal Cancer Screening Assay in Remaining Serum after Blood Biochemical Test, Clinical Chemistry and Laboratory Medicine, 2019.SCI

19.   Guodong Zhao, Yaping Tian, Yingying Du, Jinli Sun, Zhenzhen Wang, Yong Ma*, Minxue Zheng*, Comparison of CerviHPV and Hybrid Capture 2 HPV Tests for Detection of High-risk HPV Infection in Cervical Swab Specimens, Diagnostic Cytopathology, 2018.SCI

20.   Guodong Zhao, Zhaocheng Liu, Yaping Tian, Minsheng Zhu, Shouli Wang, Hui Wang, Shen Gao, Yong Ma* and Minxue Zheng*, Stability, Integrity and Recovery Rate of Cellular Nucleic Acids Preserved in a New Liquid-Based Cytology Medium, Diagnostic Cytopathology, 2018.SCI

21.   Yong Ma, Adrian Creanga, Lawrence Lum, Philip A. Beachy*, Prevalence of Off-Target Effects in Drosophila RNA Interference Screens, Nature, 2006.SCI

22.   Yong Ma, Alfrun Erkner, Ruoyu Gong, Shenqin Yao, Jussi Taipale, Konrad Basler, Philip A. Beachy*, Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched, Cell, 2002.SCI

23.   Chien-Huan Chen, Doris P. Von Kessler, Woojin Park, Baolin Wang, Yong Ma, Philip A. Beachy*, Nuclear Trafficking of Cubitus interruptus in the Transcriptional Regulation of Hedgehog Target Gene Expression, Cell, 1999.SCI

24.   Jeffery A. Porter, Stephen C. Ekker, Woo-Jin Park, Doris P. von Kessler, Keith E. Yong, Chien-Huan Chen, Yong Ma, Amina S. Woods, Robert J. Cotter, Eugene V. Koonin, Philip A. Beachy*, Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain, Cell, 1996.SCI

 

 

 

 知識產權:                                                                                                     

 

1.             鄭岷雪,馬勇,趙國棟,劉派,李甲,宮頸細胞保存及DNA快速提取一體試劑盒和提取方法,發明專利,ZL201510896289.4

2.             鄭岷雪,馬勇,趙國棟,高信噪比多探針PCR Taqman探針及其應用,發明專利,ZL 201710184261.7

3.             鄭岷雪,馬勇,趙國棟,對多種高危型人乳頭瘤病毒實現分型的試劑盒,發明專利,ZL201711367631.7

4.             劉兆成,馬勇,鄭岷雪,趙國棟,熊尚岷,用于提高具有二級結構的單鏈核酸分子的復制效率的試劑、核酸片段復制方法、應用,PCT國際專利,PCT/CN2021/131637

5.             顧兵,陳瑩,趙呈雪,張林艷,馬勇,鄭岷雪,在單管qPCR中同時檢測多種腸道致病菌的組合物、試劑盒及方法,發明專利,202111168379.3

6.             陳瑩,顧兵,趙呈雪,張林艷,馬勇,鄭岷雪,使用多重qPCR快速檢測并鑒定多種腸道致病菌的組合物、試劑盒及方法,發明專利,202111168378.9

7.             劉兆成,馬勇,鄭岷雪,趙國棟,熊尚岷,用于提高具有二級結構的單鏈核酸分子的復制效率的試劑、核酸片段復制方法、應用,發明專利,202011442674.9

8.             劉兆成,馬勇,鄭岷雪,趙國棟,熊尚岷,張春,用于提高腺相關病毒反向末端重復序列的復制效率的試劑 、腺相關 病毒DNA的復制方法、應用,發明專利,202011442675.3

9.             杜瑩瑩,古潔若,馬勇,鄭岷雪,痛風差異表達基因檢測與急性發作預警試劑盒,發明專利,201810978764.6

10.         鄭岷雪,馬勇,趙國棟,對多種高危型人乳頭瘤病毒實現分型的試劑盒,發明專利,ZL201711367631.7

11.         S. Bartz, D. Brown, Y. Ma, RNA Interference Mediated Inhibition of Isocitrate Dehydrogenase (IDH1) Gene Expression Using Short Interfering Nucleic Acid (siNA), 美國專利,US 9,322,020 B2

12.         S. Bartz, D. Brown, Y. Ma, J. Semyonov, RNA Interference Mediated Inhibition of Mitogen-activated Protein Kinase 1 (MAPK1) Gene Expression Using Short Interfering Nucleic Acid (siNA). Pending patent application with US Patent and Trademark Office, 國際專利, WO2012021383 A3

13.         S. Bartz, D. Brown, E. A. Harrington, Y. Ma, U. Philippar, RNA Interference Mediated Inhibition of MET Gene Expression Using Short Interfering Nucleic Acid (siNA). Pending patent application with US Patent and Trademark Office, 國際專利,WO2011130065 A1

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