鄭岷雪  研究員  

研究方向:

電子郵件:minxue.zheng@sibet.ac.cn

電       話:0512-69588295

通訊地址:江蘇省蘇州市高新區科技城科靈路88號

簡       歷:

從事臨床體外診斷研發和產業化二十多年。2014年回國任中國科學院“百人計劃”特聘研究員,博士生導師,依托中國科學院蘇州生物醫學工程技術研究所建立核酸檢測技術研究中心;承擔或驗收多項國家和地方重大研發項目?;貒霸诿绹韫葥?/span>BioChain公司首席技術官;在美國拜耳診斷和西門子醫療(Bayer DiagnosticsSiemens Healthcare Diagnostics)擔任主任科學家十二年。國家高端外國專家;姑蘇創新創業領軍人才;江蘇省雙創領軍人才;國家藥監局器審中心評審專家;江蘇省人才創新創業促進會會員;江蘇省免疫學會轉化醫學專業委員會“產學研學組”常務委員;北美華人生物醫藥協會(CABS)主任委員,終身會員;美國國家癌癥中心(NCI),NIH腫瘤早期診斷研究協會(EDRN)會員、PI。

獲獎及榮譽:

1、 國家高端外國專家(2021

2、 江蘇省雙創領軍人才(2015

3、 蘇州市緊缺高層次人才(2015

4、 蘇州市姑蘇創新創業領軍人才(2014

5、 蘇州市高新區科技創新創業領軍人才(2014

6、 中國科學院蘇州生物醫學工程技術研究所首屆先進生物醫學工程項目商業計劃書比賽等獎(2014

7、 中國科學院百人計劃2014

8、 美國硅谷BioChain公司,成功完成甲基化大腸癌篩查DNA提取和質控試劑盒量產,獲得CFDA醫療器械產品注冊證;成功完成NGS測序技術標記實體腫瘤FFPE樣品基因組項目,形成CancerSeq系列產品(2013

9、 美國硅谷BioChain公司,成功完成無創大腸癌早期篩查分子診斷技術在中國獨家技術轉讓和量產;完成FFPE樣品提取核酸的項目,并成功轉入生產(2013

10、 美國西門子公司,服務十年榮譽獎(2011

11、 美國西門子診斷,啟動實施科研項目高通量DNA二代測序(NGS)和云計算方法用于    艾滋病個性化治療,并同美國Illumina公司結盟,為NGS平臺MySeq進入臨床診斷奠定了基礎(2010

12、 西門子公司全球高管培訓學校榮譽獎2009

13、 美國拜耳診斷/西門子診斷,構建并領導宮頸癌篩查研發團隊,成功開創了世界領先的生物信息系統熱力學方法來解決多重核酸雜交的摸擬計算,大大降低體外診斷產品研發周期和成本2008

14、 美國拜耳公司,科學技術榮譽獎2006

15、 美國拜耳公司,團隊榮譽獎2005

16、 美國加州大學伯克利分校,采用高分辨NMR和同位素標定方法解決了世界上最大的  RNA酶三維分子結構(發表于2001PNAS雜志)(2000

17、 美國加州大學伯克利分校PMMB Fellow (Program in Mathematics and Molecular Biology)1998

18、 美國Bayer Foundation Scholarship, Univ. Houston1998

19、 美國Welch Foundation Fellowship, Univ. Houston1995

社會任職:

研究方向:

1、 分子診斷、體外診斷、精準醫療

2、 腫瘤早期篩查和診斷

3、 核酸熱力學

承擔項目情況:

代表論著:

1.     Cao, Y., Zhao, G., Tian, Y., Chen, Z., Liu, X., Yuan, M., Yang, J., Wang, X., Ma, Y., Liu, Z., Xiong, S*., Zheng, M*., Fei, S*., Feasibility of methylated CLIP4 in stool for early detection of colorectal cancer: a training study in Chinese population, Frontiers in Oncology, 2021.SCI

2.     Zhang, G., He, F., Zhao, G., Huang, Z., Li, X., Xia, X., Guo, Y., Xu, W., Xiong, S., Ma, Y., Zheng, M*., Liu, W*., Combining serum DNA methylation biomarkers and protein tumor markers improved clinical sensitivity for early detection of colorectal cancer, International Journal of Genomics, 2021.SCI

3.     Liu, Z., Zhao, C., Zhao, G., Xiong, S*., Ma, Y*., Zheng, M*., Disruptors, a new class of oligonucleotide reagents, significantly improved PCR performance on templates containing stable intramolecular secondary structures, Analytical Biochemistry, 2021.SCI

4.     Zhao, G., Liu, X., Liu, Y., Ma, Y., Yang, J., Li, H., Xiong, S., Fei, Y*., Zheng, M*., Zhao, X*., Methylated SFRP2 and SDC2 in Stool Specimens for Colorectal Cancer Early Detection: A Cost-effective Strategy for Chinese Population, Journal of Cancer, 2021.SCI

5.     Cao, Y., Zhao, G., Yuan, M., Liu, X., Ma, Y., Cao, Y., Miao, B., Zhao, S., Li, D., Xiong, S*., Zheng, M*., Fei, S*., KCNQ5 and C9orf50 methylation in stool DNA for early detection of colorectal cancer, Frontiers in Oncology, 2021.SCI

6.     Zhao, G., Wang, Z., Xiong, S., Liu, X., Zhu, Y., Li, S., Ma, Y*., Zheng, M*., Feasibility of Multiplex Methylated DNA Testing in Serum for Detection of Upper Gastrointestinal Tract Cancers, Test Engineering and Management, 2020.SCI

7.     Zhao, G., Liu, X., Liu, Y., Li, H., Ma, Y., Li,S., Zhu, Y., Miao, J.,Xiong, S*., Fei, S* Zheng, M*., Aberrant DNA Methylation of SEPT9 and SDC2 in Stool Specimens as an Integrated Biomarker for Clolorectal Cancer Early Detection, Front Genet, 2020.SCI

8.     Zhao, G., Ma, Y., Li, H., Li, S., Zhu, Y., Liu, X., Xiong, S., Liu, Y., Miao, J., Fei, S*., Zheng, M*., Zhao, X*., A novel plasma based early colorectal cancer screening assay based on methylated SDC2 and SFRP2, Clinica Chimica Acta, 2020.SCI

9.     Miao, J., Liu, Y., Zhao, G., Liu, X., Ma, Y., Li, H., Li,S., Zhu, Y., Xiong, S*., Zheng, M*., Fei, S*., Feasibility of plasma methylated SFRP2 for early detection of gastric cancer, Cancer Control, 2020.SCI

10. Zhao, G., Liu, Y., Miao, J., Li, H., Ma, Y., Liu, X., Li,S., Zhu, Y., Xiong, S*., Zheng, M*., Fei, S*., Performance comparison between plasma and stool methylated SEPT9 tests for detecting colorectal cancer, Frontiers in Genetics, 2020.SCI

11. Liu, Z., Sun, J., Zhao, G., Xiong, S., Ma, Y., Zheng, M*., Transient stem-loop structure of nucleic acid template may interfere with__polymerase chain reaction through endonuclease activity of Taq DNA__polymerase, Gene, 2020.SCI

12. Zhao, G., Li, H., Yang, Z., Wang, Z., Xu, M., Xiong, S., Li, S., Wu,  X., Liu, X., Wang, Z., Zhu, Y., Ma, Y*., Fei, S*., Zheng, M*., Multiplex Methylated DNA Testing in Plasma with High Sensitivity and Specificity for Colorectal Cancer Screening, Cancer Medicine, 2020.SCI

13. Sun, J., Tian, Y., Du, Y., Wang, Z., Zhao, G*., Ma, Y*., Zheng, M*., A Cautionary Tale of Cross Contamination among Plasmids from Commercial Suppliers, Biotechniques, 2020.SCI

14. Sun, J., Shi, Y., DU, Y., Wang, Z., Liu, Z., Wang, H., Zhao,G*., Ma, Y*., Zheng, M*., Rapid detection of diarrheagenic Escherichia coli in food by a new multiplex real-time Quantitative PCR Assay, Applied Biochemistry and Microbiology, 2020.SCI

15. Du, Y., Zhao, G., Liu, Z., Sun, J., Zheng, M*., Ma, Y*., Comparison of CerviHPV and cobas 4800 HPV Tests for Detection of High-risk HPV Infection in Cervical Swab Specimens, Journal of Reproductive Medicine, 2020.SCI 

16. Li, H., Wang, Z., Zhao, G., Ma, Y., Chen, Y., Xue, Q., Zheng, M*., Fei, S*., Performance of a MethyLight assay for methylated SFRP2 DNA detection in colorectal cancer tissue and serum, The International Journal of Biological Markers, 2019. SCI

17. Chen, Y., Wang, Z., Zhao, G., Sun, C., Ma, Y., Zhang, L., Zheng, M*., Li, H*., Performance of a Novel Blood based Early Colorectal Cancer Screening Assay in Remaining Serum after Blood Biochemical Test, Clinical Chemistry and Laboratory Medicine, 2019.SCI

18. Zhao, G., Tian, Y., Du, Y., Sun, J., Wang, Z., Ma, Y*., Zheng, M*., Comparison of CerviHPV and Hybrid Capture 2 HPV Tests for Detection of High-risk HPV Infection in Cervical Swab Specimens, Diagnostic Cytopathology, 2018.SCI

19. Zhao, G., Liu, Z., Tian, Y., Zhu, M., Wang, S., Wang, H., Gao, S., Ma, Y*., Zheng, M*., Stability, Integrity and Recovery Rate of Cellular Nucleic Acids Preserved in a New Liquid-Based Cytology Medium, Diagnostic Cytopathology, 2018.SCI

20. Hu, R., Zheng, M., Wu, J., Li, C., Shen, D., Yang, D., Li, L., Ge, M., Chang, and Dong, W. Core-Shell Magnetic Gold Nanoparticles for Magnetic Field-Enhanced Radio-Photothermal Therapy in Cervical Cancer, Nanomaterials, 2017.SCI

21. Zheng, M., Han, X., Gao, X., Strand polarity of trinucleotide repeat sequences: NMR studies parallel/anti-parallel duplex, {d(GAC)3}2, Protein Data Bank, 2003.SCI

22. Zheng, M., Wu, M., Tinoco, I. Jr., Formation of a GNRA tetraloop in the extended P5abc subdomain of Tetrahymena group I ribozyme can disrupt an inter-domain interaction, Proc. Natl. Acad. Sci. USA 98, 2001.SCI

23. Kao, C., Rudisser, S., Zheng, M., A simple and efficient method to transcribe RNAs with reduced 3' heterogeneity, Methods, 2001.SCI

24. Kao, C., Rudisser, S., Zheng, M., A simple and efficient method to transcribe RNAs with homogenous 3’ Ends. Promega Notes, 2001.SCI

25. Zheng, M., Tinoco, I. Jr., High resolution NMR spectroscopy of ribozymes. In Ribozyme Biochemistry and Biotechnology. 297-314, Eds. Krupp. G. and Gaur, R. Eaton Publishing, Natick, [Invited book chapter], 2000.

26. Zheng, M., Wu, M., Silverman, S., Cech, T., Tinoco, I., Jr., RNA folding and mutation studies of the P5abc subdomain from the tetrahymena group I intron ribozyme, FASEB Journal, 1999.SCI

27. Silverman, S., Zheng, M., Wu, M., Tinoco, I. Jr., Cech, T. R., Quantifying the energy interplay of RNA tertiary and secondary structure interactions, RNA, 1999.SCI

28. Kao, C., Zheng, M., Rudisser, S., A simple and efficient method to reduce nontemplated nucleotide addition at the 3' terminus of RNAs transcribed by T7 RNA polymerase, RNA 5, 1999.SCI

29. Gao, X., Huang, X., Smith, G. K., Zheng, M., Structure and dynamics of single stranded nucleic acids containing trinucleotide repeats. In Genetic instabilities and hereditary neurological diseases, 623-644. Eds. Warren, S. T. and Wells, R. D., Academic Press, San Diego, [Invited review], 1998.

30. Gao, X., Huang, X., Zheng, M., Smith, G. K., Ji, J., Structure, flexibility and folding of single stranded DNA triplet repeats. Biophysical Journal, 1998.SCI

31. Zheng, M., Study of the structure and stability of DNA trinucleotide repeat sequences by nuclear magnetic resonance spectroscopy, Ph.D.Thesis, Department of Chemistry, University of Houston, 1997.

32. Zheng, M., Huang, X., Smith, K., Yang, X., Gao, X., Genetically unstable CXG repeats are structurally dynamic and have a high propensity for folding, An NMR and UV spectroscopic study, J. Mol. Biol, 1996.SCI

33. Gao, X., Huang, X., Smith, G. K., Zheng, M., Liu. H, A new antiparallel duplex Motif of DNA CCG repeats that is stabilized by extrahelical bases symmetrically located in the minor groove, J. Am. Chem. Soc, 1995.SCI

34. Gao, X., Smith, K., Huang, X., Zheng, M, Unusual solution structures unveiled by NMR studies of single-stranded DNA triplet repeats, FASEB Journal, 1995.SCI

35. Wang, W., Liang, C., Zheng, M., Gao, X., Selective acylation of N-(2-Phosphonoethyl) ethylenediamine phosphonates, Tetrahedron Letters 36, 1995.SCI

 

知識產權:                                                                                                     

1.       鄭岷雪,馬勇,趙國棟,劉派,李甲,宮頸細胞保存及DNA快速提取一體試劑盒和提取方法,發明專利,ZL201510896289.4

2.       鄭岷雪,馬勇,趙國棟,高信噪比多探針PCR Taqman探針及其應用,發明專利,ZL 201710184261.7

3.       鄭岷雪,馬勇,趙國棟,對多種高危型人乳頭瘤病毒實現分型的試劑盒,發明專利,ZL201711367631.7

4.       劉兆成,馬勇,鄭岷雪,趙國棟,熊尚岷,用于提高具有二級結構的單鏈核酸分子的復制效率的試劑、核酸片段復制方法、應用,PCT國際專利,PCT/CN2021/131637

5.       顧兵,陳瑩,趙呈雪,張林艷,馬勇,鄭岷雪,在單管qPCR中同時檢測多種腸道致病菌的組合物、試劑盒及方法,發明專利,202111168379.3

6.       陳瑩,顧兵,趙呈雪,張林艷,馬勇,鄭岷雪,使用多重qPCR快速檢測并鑒定多種腸道致病菌的組合物、試劑盒及方法,發明專利,202111168378.9

7.       劉兆成,馬勇,鄭岷雪,趙國棟,熊尚岷,用于提高具有二級結構的單鏈核酸分子的復制效率的試劑、核酸片段復制方法、應用,發明專利,202011442674.9

8.       劉兆成,馬勇,鄭岷雪,趙國棟,熊尚岷,張春,用于提高腺相關病毒反向末端重復序列的復制效率的試劑 、腺相關 病毒DNA的復制方法、應用,發明專利,202011442675.3

9.       杜瑩瑩,古潔若,馬勇,鄭岷雪,痛風差異表達基因檢測與急性發作預警試劑盒,發明專利,201810978764.6

10.    鄭岷雪,馬勇,趙國棟,對多種高危型人乳頭瘤病毒實現分型的試劑盒,發明專利,ZL201711367631.7

11.    Zheng, M., Quinn, J., Warner, B., Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation. 美國專利, US Patent No. US 8394944 B2

12.    Zheng, M., Ku, L., Shen, L., Wong, C., Bush-Donovan, C., Reagents and methods for detecting CYP2C9 polymorphisms, 英國專利,EP2111465B1

13.    Battersby, T., Fehr, A., Zheng, M., A method of normalizing biological samples, 國際專利, 2014015098 A1

14.    Fehr, A., Battersby, T., Zheng, M., Dynamic Range Compression of Nucleic Acid Library Input for Next Generation Sequencing Systems. 美國專利,2012P10835US

15.    Zheng, M., Ahle, D., Warner, B., Wu, M. and Chang, C., Highly orthogonal universal sequences for use in nucleic acid assays, 美國專利,US8063196B2

16.    Zheng, M., Ahle, D., Warner, B., Wu, M., Chang, C, An orthogonal set of universal probe sequences for nucleic acid hybridization assays, 美國專利,US Patent application No. 11/049,465.

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